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Article

Inactivating Mutations in SWI/SNF Chromatin Remodeling Genes in Human Cancer

30 Jul 2013

Abstract excerpt

Chromosomal deoxyribonucleic acid and histone proteins form a highly condensed structure known as chromatin. Chromatin remodeling proteins regulate deoxyribonucleic acid transcription, synthesis and repair by changing nucleosomal composition in an adenosine triphosphate-dependent manner and mediate access of deoxyribonucleic acid-binding proteins to deoxyribonucleic acid double strands. Recently, large-scale...

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PMID: 23904343
DOI: 10.1093/jjco/hyt101

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