Article

GDF15 mediates inflammation-associated bone loss through a brain-bone axis

2023-11-23

Abstract excerpt

<h4>SUMMARY</h4> Metabolic mediators play an important role in regulating chronic inflammation in the body. Here we report an unexpected role for GDF15 (Growth Differentiation Factor 15), a central mediator of food intake, in inflammation-associated bone loss. GDF15 serum levels were found to be elevated in arthritis patients and inversely correlated with bone density. Despite being associated with inflammation,...

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Literature Corpus work: a770bef5-e053-52d1-bed0-14873adf830d
DOI: 10.1101/2023.11.22.568290

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