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Aurora kinase A controls meiosis I progression in mouse oocytes

1 Aug 2008

Abstract excerpt

Aurora kinase A (AURKA), which is a centrosome-localized serine/threonine kinase crucial for cell cycle control, is critically involved in centrosome maturation and spindle assembly in somatic cells. Active T288 phosphorylated AURKA localizes to the centrosome in the late G(2) and also spreads to the minus ends of mitotic spindle microtubules. AURKA activates centrosomal CDC25B and recruits cyclin B1 to...

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PMID: 18677115
DOI: 10.4161/cc.6361

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