Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B

26 Oct 2021

Abstract excerpt

A hallmark of advanced maternal age is a significant increase in meiotic chromosome segregation errors, resulting in early miscarriages and congenital disorders. These errors most frequently occur during meiosis I (MI). The spindle assembly checkpoint (SAC) prevents chromosome segregation errors by arresting the cell cycle until proper chromosome alignment is achieved. Unlike in mitosis, the SAC in oocytes is...

Topics

Join the communities discussing this publication.

Epigenetics and DNA Methylation
Microtubule and mitosis dynamics
Reproductive Biology and Fertility

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34704342
DOI: 10.1111/acel.13489

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age‐dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase BPMID 34704342Read ↗

Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged miceSemantic proximity Read ↗

Chromosomal and cytoplasmic context determines predisposition to maternal age-related aneuploidy: brief overview and update on MCAK in mammalian oocytesSemantic proximity Read ↗

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errorsSemantic proximity Read ↗

Evidence That a Defective Spindle Assembly Checkpoint Is Not the Primary Cause of Maternal Age-Associated Aneuploidy in Mouse Eggs1Semantic proximity Read ↗

Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stressSemantic proximity Read ↗

Chromosome Segregation in the Oocyte: What Goes Wrong during AgingSemantic proximity Read ↗

Maternal age-dependent APC/C-mediated decrease in securin causes premature sister chromatid separation in meiosis II.Semantic proximity Read ↗

Why is Chromosome Segregation Error in Oocytes Increased With Maternal Aging?Semantic proximity Read ↗

Age-dependent loss of cohesion protection in human oocytesSemantic proximity Read ↗

Human female meiosis revised: new insights into the mechanisms of chromosome segregation and aneuploidies from advanced genomics and time-lapse imagingSemantic proximity Read ↗

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1Semantic proximity Read ↗

Kinetochore microtubule establishment is defective in oocytes from aged miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.