Article

Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits

2021-12-08

Abstract excerpt

Despite the growing number of genome-wide association studies (GWAS), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has been difficult to quantify because GWAS are generally underpowered to detect individual interactions of small effect. Here, we develop a method to test for genetic int...

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Literature Corpus work: a74377f3-f7c8-518c-bcc3-886db24c8583
DOI: 10.1101/2021.12.06.471235

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