Article
Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits.
American journal of human genetics - 7 Jul 2022
Patel Roshni A, Musharoff Shaila A, Spence Jeffrey P, Pimentel Harold, Tcheandjieu Catherine, Mostafavi Hakhamanesh, Sinnott-Armstrong Nasa, Clarke Shoa L, Smith Courtney J, Durda Peter P, Taylor Kent D, Tracy Russell, Liu Yongmei, Johnson W Craig, Aguet Francois, Ardlie Kristin G, Gabriel Stacey, Smith Josh, Nickerson Deborah A, Rich Stephen S, Rotter Jerome I, Tsao Philip S, Assimes Themistocles L, Pritchard Jonathan K
Abstract excerpt
Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has been difficult to quantify because GWASs are generally underpowered to detect individual interactions of small effect. Here, we develop a method to test for genetic...
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