Article
Topological linkage disequilibrium calculated from coalescent genealogies
2018-03-22
Abstract excerpt
We revisit the classical concept of two-locus linkage disequilibrium ( LD ) and introduce a novel way of looking at haplotypes. In contrast to defining haplotypes as allele combinations at two marker loci, we concentrate on the clustering of sampled chromosomes induced by their coalescent genealogy. The root of a binary coalescent trees defines two clusters of chromosomes. At two different loci this assignment ma...
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Identifiers and source
- Literature Corpus work
- a722d010-5a04-5d93-bdb0-3e6cdda0d333
- DOI
- 10.1101/286393