Article
cLD: Rare-variant linkage disequilibrium between genomic regions identifies novel genomic interactions.
PLoS genetics - 1 Dec 2023
Wang Dinghao, Perera Deshan, He Jingni, Cao Chen, Kossinna Pathum, Li Qing, Zhang William, Guo Xingyi, Platt Alexander, Wu Jingjing, Zhang Qingrun
Abstract excerpt
Linkage disequilibrium (LD) is a fundamental concept in genetics; critical for studying genetic associations and molecular evolution. However, LD measurements are only reliable for common genetic variants, leaving low-frequency variants unanalyzed. In this work, we introduce cumulative LD (cLD), a stable statistic that captures the rare-variant LD between genetic regions, which reflects more biological...
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