Article
Linkage disequilibrium: what history has to tell us.
Trends in genetics : TIG - 1 Feb 2002
Nordborg Magnus, Tavaré Simon
Abstract excerpt
Linkage disequilibrium has become important in the context of gene mapping. We argue that to understand the pattern of association between alleles at different loci, and of DNA sequence polymorphism in general, it is useful first to consider the underlying genealogy of the chromosomes. The stochastic process known as the coalescent is a convenient way to model such genealogies, and in this paper we set out the...
Topics
- Genetic Variation
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Mutation
- Population Density
- Recombination, Genetic
- Selection, Genetic