Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion.

doi:10.1086/323251

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Article

Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion.

American journal of human genetics - 1 Sept 2001

Ardlie K, Liu-Cordero S N, Eberle M A, Daly M, Barrett J, Winchester E, Lander E S, Kruglyak L

Abstract excerpt

Understanding the pattern of linkage disequilibrium (LD) in the human genome is important both for successful implementation of disease-gene mapping approaches and for inferences about human demographic histories. Previous studies have examined LD between loci within single genes or confined genomic regions, which may not be representative of the genome; between loci separated by large distances, where little LD...

Topics

Computer Simulation
Gene Conversion
Genome, Human
Genotype
Humans
Linkage Disequilibrium

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PMID: 11473344
DOI: 10.1086/323251
PMCID: PMC1235487

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