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Article

Topological Data Analysis Generates High-Resolution, Genome-wide Maps of Human Recombination.

Cell systems - 1 Jul 2016

Camara Pablo G, Rosenbloom Daniel I S, Emmett Kevin J, Levine Arnold J, Rabadan Raul

Abstract excerpt

Meiotic recombination is a fundamental evolutionary process driving diversity in eukaryotes. In mammals, recombination is known to occur preferentially at specific genomic regions. Using topological data analysis (TDA), a branch of applied topology that extracts global features from large data sets, we developed an efficient method for mapping recombination at fine scales. When compared to standard linkage-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27345159
DOI: 10.1016/j.cels.2016.05.008
PMCID: PMC4965322

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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