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Article

Association mapping and significance estimation via the coalescent.

American journal of human genetics - 1 Dec 2008

Kimmel Gad, Karp Richard M, Jordan Michael I, Halperin Eran

Abstract excerpt

The central questions asked in whole-genome association studies are how to locate associated regions in the genome and how to estimate the significance of these findings. Researchers usually do this by testing each SNP separately for association and then applying a suitable correction for multiple-hypothesis testing. However, SNPs are correlated by the unobserved genealogy of the population, and a more powerful...

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PMID: 19026399
DOI: 10.1016/j.ajhg.2008.10.017
PMCID: PMC2668060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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