Article

Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participants

2025-06-13

Abstract excerpt

Brain structural volumes are highly heritable and are linked to multiple neuropsychological outcomes, including Alzheimer’s disease (AD). Genome-wide association studies have successfully identified genetic variants associated with intracranial volume (ICV), total brain volume (TBV), hippocampal volume (HV), and lateral ventricular volume (LVV). However, these studies mostly focused on common genetic variants with...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a72021d9-6817-553e-a793-438fb5dc4ae5
DOI: 10.1101/2025.06.11.25329426

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Whole genome sequence association analysis of brain structural volume measures in the NHLBI TOPMed Program highlights novel loci in diverse participantsDOI 10.1101/2025.06.11.25329426Read

Identification of common variants associated with human hippocampal and intracranial volumes.Semantic proximity Read

Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits.Semantic proximity Read

Whole genome sequence analyses of brain imaging measures in the Framingham Study.Semantic proximity Read

GWAS of 19,629 individuals identifies novel genetic variants for regional brain volumes and refines their genetic co-architecture with cognitive and mental health traitsSemantic proximity Read

Whole-genome sequencing reveals variant associations with brain imaging phenotypesSemantic proximity Read

Volumetric GWAS of medial temporal lobe structures identifies an ERC1 locus using ADNI high-resolution T2-weighted MRI data.Semantic proximity Read

Whole-genome analyses of whole-brain data: working within an expanded search space.Semantic proximity Read

Multiple loci influencing hippocampal degeneration identified by genome scan.Semantic proximity Read

Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data.Semantic proximity Read

Genome-wide association study of white matter hyperintensity volume in elderly persons without dementia.Semantic proximity Read

Identification of novel associations of candidate loci with Alzheimer’s disease by leveraging the shared genetic basis with hippocampal volumeSemantic proximity Read

Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.Semantic proximity Read