Article
Genetic architectures of the human hippocampus and those involved in neuropsychiatric traits.
BMC medicine - 11 Oct 2024
Ning Caibo, Jin Meng, Cai Yimin, Fan Linyun, Hu Kexin, Lu Zequn, Zhang Ming, Chen Can, Li Yanmin, Hu Naifan, Zhang Donghui, Liu Yizhuo, Chen Shuoni, Jiang Yuan, He Chunyi, Wang Zhuo, Cao Zilong, Li Hanting, Li Gaoyuan, Ma Qianying, Geng Hui, Tian Wen, Zhang Heng, Yang Xiaojun, Huang Chaoqun, Wei Yongchang, Li Bin, Zhu Ying, Li Xiangpan, Miao Xiaoping, Tian Jianbo
Abstract excerpt
BACKGROUND: The hippocampus, with its complex subfields, is linked to numerous neuropsychiatric traits. While most research has focused on its global structure or a few specific subfields, a comprehensive analysis of hippocampal substructures and their genetic correlations across a wide range of neuropsychiatric traits remains underexplored. Given the hippocampus's high heritability, considering hippocampal and...
Topics
- Humans
- Hippocampus
- Genome-Wide Association Study
- Female
- Male
- Magnetic Resonance Imaging
- Multifactorial Inheritance
- Mental Disorders
- Mendelian Randomization Analysis