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Article

Whole genome sequence analyses of brain imaging measures in the Framingham Study.

Neurology - 16 Jan 2018

Sarnowski Chloé, Satizabal Claudia L, DeCarli Charles, Pitsillides Achilleas N, Cupples L Adrienne, Vasan Ramachandran S, Wilson James G, Bis Joshua C, Fornage Myriam, Beiser Alexa S, DeStefano Anita L, Dupuis Josée, Seshadri Sudha

Abstract excerpt

OBJECTIVE: We sought to identify rare variants influencing brain imaging phenotypes in the Framingham Heart Study by performing whole genome sequence association analyses within the Trans-Omics for Precision Medicine Program. METHODS: We performed association analyses of cerebral and hippocampal volumes and white matter hyperintensity (WMH) in up to 2,180 individuals by testing the association of rank-normalized...

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Identifiers

PMID: 29282330
DOI: 10.1212/WNL.0000000000004820
PMCID: PMC5772158

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UNC5D

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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