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Article

Multiple loci influencing hippocampal degeneration identified by genome scan.

Annals of neurology - 1 Jul 2012

Melville Scott A, Buros Jacqueline, Parrado Antonio R, Vardarajan Badri, Logue Mark W, Shen Li, Risacher Shannon L, Kim Sungeun, Jun Gyungah, DeCarli Charles, Lunetta Kathryn L, Baldwin Clinton T, Saykin Andrew J, Farrer Lindsay A

Abstract excerpt

OBJECTIVE: Large genome-wide association studies (GWASs) have identified many novel genes influencing Alzheimer disease (AD) risk, but most of the genetic variance remains unexplained. We conducted a 2-stage GWAS for AD-related quantitative measures of hippocampal volume (HV), total cerebral volume (TCV), and white matter hyperintensities (WMH). METHODS: Brain magnetic resonance imaging measures of HV, TCV, and...

Topics

Aged
Aged, 80 and over
Alzheimer Disease
Cognitive Dysfunction
Disease Progression
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hippocampus

Humans

Magnetic Resonance Imaging

Male

Middle Aged

Nerve Degeneration

Neuroimaging

Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 22745009
DOI: 10.1002/ana.23644
PMCID: PMC3405172

Genes

APOE
GCFC2
PICALM
SELP
SYNPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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