Article

Ubiquinone deficiency drives reverse electron transport to disrupt hepatic metabolic homeostasis in obesity

2023-02-22

Abstract excerpt

Mitochondrial reactive oxygen species (mROS) are central to physiology. While excess mROS production has been associated with several disease states, its precise sources, regulation, and mechanism of generation in vivo remain unknown, limiting translational efforts. Here we show that in obesity, hepatic ubiquinone (Q) synthesis is impaired, which raises the QH 2 /Q ratio, driving excessive mROS production via re...

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Literature Corpus work: a71af1a9-2723-5e82-9764-7956de6714ac
DOI: 10.1101/2023.02.21.528863

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