Article
Mitochondrial Reactive Oxygen Species Mediate Cardiac Structural, Functional, and Mitochondrial Consequences of Diet-Induced Metabolic Heart Disease.
Journal of the American Heart Association - 11 Jan 2016
Sverdlov Aaron L, Elezaby Aly, Qin Fuzhong, Behring Jessica B, Luptak Ivan, Calamaras Timothy D, Siwik Deborah A, Miller Edward J, Liesa Marc, Shirihai Orian S, Pimentel David R, Cohen Richard A, Bachschmid Markus M, Colucci Wilson S
Abstract excerpt
BACKGROUND: Mitochondrial reactive oxygen species (ROS) are associated with metabolic heart disease (MHD). However, the mechanism by which ROS cause MHD is unknown. We tested the hypothesis that mitochondrial ROS are a key mediator of MHD. METHODS AND RESULTS: Mice fed a high-fat high-sucrose (HFHS) diet develop MHD with cardiac diastolic and mitochondrial dysfunction that is associated with oxidative...
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