Article
Sex and BNIP3 genotype, rather than acute lipid injection, modulate hepatic mitochondrial function and steatosis risk in mice.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 May 2020
Fuller Kelly N Z, McCoin Colin S, Allen Julie, Bell-Glenn Shelby, Koestler Devin C, Dorn Gerald W, Thyfault John P
Abstract excerpt
Both lipid oversupply and poor mitochondrial function (low respiration and elevated H2O2 emission) have been implicated in the development of hepatic steatosis and liver injury. Mitophagy, the targeted degradation of low-functioning mitochondria, is critical for maintaining mitochondrial quality control. Here, we used intralipid injection combined with acute (4 day) and chronic (4-7wk) high-fat diets (HFD) to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.