Article
Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation.
Free radical research - 1 Dec 2018
Chokchaiwong Suphannee, Kuo Yung-Ting, Lin Shih-Hsiang, Hsu Yi-Ching, Hsu Sung-Po, Liu Yu-Ting, Chou An-Je, Kao Shu-Huei
Abstract excerpt
Multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive metabolic disorder of fatty acid metabolism, is mostly caused by mutations in the ETFA, ETFB or ETFDH genes that result in dysfunctions in electron transfer flavoprotein (ETF) or electron transfer flavoprotein-ubiquinone dehydrogenase (ETFDH). In β-oxidation, fatty acids are processed to generate acyl-CoA, which is oxidised by flavin...
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