HDAC7 is a specific therapeutic target in Acute Erythroid Leukemia

Abstract excerpt

<title>Abstract</title> <p>Acute erythroleukemia (AEL) is a rare subtype of acute myeloid leukemia with a poor prognosis. In this study, we established a novel murine AEL model with <italic>Trp53</italic> depletion and ERG overexpression. ERG overexpression in <italic>Trp53</italic>-deficient mouse bone marrow cells, but not in wild-type bone marrow cells, leads to AEL development within two months after transpla...

Topics

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• Acute Myeloid Leukemia Research
• Exome
• Histone Deacetylase Inhibitors Research
• Leukemia, Erythroblastic, Acute
• Leukemia, Myeloid, Acute
• Mutation
• Protein Degradation and Inhibitors
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

a716fd8a-6096-52d0-bd80-e8bbbc3ea80e

DOI

10.21203/rs.3.rs-4080460/v1