Article

STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis

2024-03-05

Abstract excerpt

<title>Abstract</title> <p>Acquired pure red cell aplasia (PRCA) is anemia associated with the absence of erythroblasts and is characterized by persistent and easy recurrence. However, the underlying mechanisms of acquired PRCA remain obscure, and the role of gene mutations in the pathogenesis of acquired PRCA has not yet been reported. In the present study, we detected thirty newly diagnosed patients with acquir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ed45c72a-929b-5c8e-a85b-6fb5d9196660
DOI: 10.21203/rs.3.rs-3993951/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesisDOI 10.21203/rs.3.rs-3993951/v1Read

STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis.Semantic proximity Read

Gene mutation profile in patients with acquired pure red cell aplasia.Semantic proximity Read

TET2 and clonal hematopoiesis-related gene variants in patients with acquired pure red cell aplasiaSemantic proximity Read

Mutational heterogeneities in STAT3 and clonal hematopoiesis-related genes in acquired pure red cell aplasiaSemantic proximity Read

Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cellsSemantic proximity Read

Blood Relatives: Splicing Mechanisms underlying Erythropoiesis in Health and DiseaseSemantic proximity Read

Ribosomopathies and the paradox of cellular hypo- to hyperproliferationSemantic proximity Read

WITHDRAWN: Identification and validation of aging-related genes and their classification models based on myelodysplastic syndromesSemantic proximity Read

Distinct Stem Cell Identities Converge into Shared Erythroid Stress in ERCC6L2 Disease and Shwachman-Diamond SyndromeSemantic proximity Read

[Molecular pathogenesis and therapeutic targets in acute erythroid leukemia].Semantic proximity Read

Single-cell transcriptomic analysis identifies an immune erythroid in paroxysmal nocturnal hemoglobinuriaSemantic proximity Read

Targeting the EIF2AK1 Signaling Pathway Rescues Red Blood Cell Production in SF3B1 -Mutant Myelodysplastic Syndromes With Ringed SideroblastsSemantic proximity Read