Article
Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers.
Blood - 6 Aug 2020
Fagnan Alexandre, Bagger Frederik Otzen, Piqué-Borràs Maria-Riera, Ignacimouttou Cathy, Caulier Alexis, Lopez Cécile K, Robert Elie, Uzan Benjamin, Gelsi-Boyer Véronique, Aid Zakia, Thirant Cécile, Moll Ute, Tauchmann Samantha, Kurtovic-Kozaric Amina, Maciejewski Jaroslaw, Dierks Christine, Spinelli Orietta, Salmoiraghi Silvia, Pabst Thomas, Shimoda Kazuya, Deleuze Virginie, Lapillonne Hélène, Sweeney Connor, De Mas Véronique, Leite Betty, Kadri Zahra, Malinge Sébastien, de Botton Stéphane, Micol Jean-Baptiste, Kile Benjamin, Carmichael Catherine L, Iacobucci Ilaria, Mullighan Charles G, Carroll Martin, Valent Peter, Bernard Olivier A, Delabesse Eric, Vyas Paresh, Birnbaum Daniel, Anguita Eduardo, Garçon Loïc, Soler Eric, Schwaller Juerg, Mercher Thomas
Abstract excerpt
Acute erythroleukemia (AEL or acute myeloid leukemia [AML]-M6) is a rare but aggressive hematologic malignancy. Previous studies showed that AEL leukemic cells often carry complex karyotypes and mutations in known AML-associated oncogenes. To better define the underlying molecular mechanisms driving the erythroid phenotype, we studied a series of 33 AEL samples representing 3 genetic AEL subgroups including...
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