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HDAC7 is a potential therapeutic target in acute erythroid leukemia

14 Sept 2024

Abstract excerpt

Acute erythroleukemia (AEL) is a rare subtype of acute myeloid leukemia with a poor prognosis. In this study, we established a novel murine AEL model with Trp53 depletion and ERG overexpression. ERG overexpression in Trp53-deficient mouse bone marrow cells, but not in wild-type bone marrow cells, leads to AEL development within two months after transplantation with 100% penetrance. The established mouse AEL cells...

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PMID: 39277669
DOI: 10.1038/s41375-024-02394-5

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