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Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cells

2025-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Patients with Acute Myeloid Leukemia (AML) subtypes, acute erythroleukemia and acute megakaryocytic leukemia (M6 and M7 AMLs, respectively) have a median survival of only a few months with no targeted effective treatment. Our gene expression analysis using the Cancer Cell Line Encyclopedia and CRISPR screen from DepMap showed that M6/M7 AMLs have high levels of the transcription factor GATA1 an...

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Literature Corpus work
2c9664b2-726a-56fc-a974-472f5a2cbba4
DOI
10.1101/2025.01.19.633759
Open publication

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Fenretinide targets GATA1 to induce cytotoxicity in GATA1 positive Acute Erythroid and Acute Megakaryoblastic Leukemic cellsDOI 10.1101/2025.01.19.633759
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