Article

Astrocytes transform the transcriptomic and epigenetic landscape of developing cortical neurons to promote activity via intrinsic excitability control

2026-05-19

Abstract excerpt

Astrocytes are implicated in neuronal development and function, particularly of synapses, but their genome-wide impact is unclear. We show that cortical astrocytes trigger epigenetic remodelling in developing cortical neurons and widespread transcriptomic changes distinct from neurons’ intrinsic developmental trajectory. These changes can cause an emergence of neuronal firing activity independent of functional exc...

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Literature Corpus work: be68d73d-c319-51b3-8f48-c78d0c2aa3c4
DOI: 10.64898/2026.05.17.725732

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