Article

Rgnef regulates bone mass through the activation of RhoA and Rac1

2025-03-27

Abstract excerpt

<title>Abstract</title> <p>Rho guanine nucleotide exchange factor (Rgnef/p190RhoGEF), a RhoA-specific guanine nucleotide exchange factor, has been implicated in cancer and amyotrophic lateral sclerosis, but little is known about its role in bone. In this study, we investigated the roles of Rgnef in bone metabolism using Rgnef-deficient and overexpressing mice. Compared with littermate wild-type mice, Rgnef-defici...

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Literature Corpus work: a700963f-9574-5738-902c-9d1dedc2c090
DOI: 10.21203/rs.3.rs-6102004/v1

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