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Article

Rac1 mediates the osteoclast gains-in-function induced by haploinsufficiency of Nf1

7 Dec 2007

Abstract excerpt

Neurofibromatosis type I (NF1) is a congenital disorder resulting from loss-of-function of the tumor suppressor gene, NF1, a GTPase-activating protein for p21ras. Fifty percent of NF1 patients have osseous manifestations including a high incidence of osteoporosis. Osteoclasts are specialized macrophage/monocyte lineage-derived cells that resorb bone and NF1 haploinsufficient osteoclasts have abnormal...

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PMID: 18089636
DOI: 10.1093/hmg/ddm366

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