Article

Identification of SLC45A4 as a pain gene encoding a neuronal polyamine transporter

2024-09-30

Abstract excerpt

Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy 1 . They are implicated in multiple neurological disorders including stroke, epilepsy and neurodegeneration and can regulate neuronal excitability through interactions with ion channels 2 . Polyamines have been linked to pain showing altered levels in human persistent pain states and modulation of pa...

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Literature Corpus work: a6fa8d4e-40f5-56f5-815c-c4582d845411
DOI: 10.1101/2024.09.25.615046

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