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Article

GWAS of extended prescription analgesic use identifies genetic loci in chronic pain.

Nature communications - 28 May 2026

Harlow Charli E, Uzochukwu Emeka, Fernando Hazel A, Mordaunt Charles E, Hughey Jordan M, Eicher John D, Robinson Lara, Bowker Nicholas, Howe Laurence, Liu Jimmy, Cortes Adrian, Wilson Paul, Gungabissoon Usha, Benson Victoria S, Nash Anthony, Young Gareth, Addis Laura, Xu Chun-Fang, Webber Caleb, Davitte Jonathan, Cader M Zameel

Abstract excerpt

Pain-related conditions are the leading cause of disability worldwide. Existing GWAS for chronic pain have mainly focused on individual pain-related disorders, which may not optimally capture the phenotype. Here, we define chronic pain based on prescription analgesic use ( ≥ 90 days) in two large biobanks (UK Biobank and FinnGen). GWAS meta-analyses of 11 prescription-based pain phenotypes identify 140...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 42209495
DOI: 10.1038/s41467-026-71434-8
PMCID: PMC13402304

Genes

ARPP21
CNTNAP2
DCC
SLC39A8
TRPM8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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