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SLC45A4 is a pain gene encoding a neuronal polyamine transporter

20 Aug 2025

Abstract excerpt

Abstract Polyamines are regulatory metabolites with key roles in transcription, translation, cell signalling and autophagy1. They are implicated in multiple neurological disorders, including stroke, epilepsy and neurodegeneration, and can regulate neuronal excitability through interactions with ion channels2. Polyamines have been linked to pain, showing altered levels in human persistent pain states and...

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PMID: 40836097
DOI: 10.1038/s41586-025-09326-y

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