Article

Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation and immune regulation

2025-02-05

Abstract excerpt

<h4>Background</h4> Neuropathic pain is a common and debilitating symptom with limited treatment options. Genetic studies, which can provide vital evidence for drug development, have identified only five genome-wide significant signals for neuropathic pain traits. To address this, we performed the largest genome-wide association study (GWAS) to date of all-cause neuropathic pain and neuropathic pain subtypes. <h4>...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 114616d1-e738-53e8-a471-ade5718fc84f
DOI: 10.1101/2025.02.04.25320393

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation and immune regulationDOI 10.1101/2025.02.04.25320393Read

Genome-wide association study of neuropathic pain phenotypes implicates loci involved in neural cell adhesion, channels, collagen matrix formation, and immune regulationSemantic proximity Read

Genome-wide association study of neuropathic pain.Semantic proximity Read

Rare variant associations of chronic pain conditions in the UK Biobank Whole Exome SequencingSemantic proximity Read

Genetic studies of human neuropathic pain conditions: a review.Semantic proximity Read

DOLORisk: study protocol for a multi-centre observational study to understand the risk factors and determinants of neuropathic painSemantic proximity Read

Genetic associations of neuropathic pain and sensory profile in a deeply phenotyped neuropathy cohortSemantic proximity Read

Systematic review and meta-analysis of genetic risk factors for neuropathic pain.Semantic proximity Read

Neuropathic pain as part of chronic widespread pain: environmental and genetic influences.Semantic proximity Read

Knowledge of the genetics of human pain gained over the last decade from next-generation sequencing.Semantic proximity Read

A systematic review of genome-wide association studies for pain, nociception, neuropathy, and pain treatment responses.Semantic proximity Read

Genome-wide association study of nociceptive musculoskeletal pain treatment response in UK BiobankSemantic proximity Read

SCN9A Variants May be Implicated in Neuropathic Pain Associated With Diabetic Peripheral Neuropathy and Pain Severity.Semantic proximity Read