Article
Rare variant analyses in large-scale cohorts identified SLC13A1 associated with chronic pain.
Pain - 1 Aug 2023
Ao Xiang, Parisien Marc, Zidan Maha, Grant Audrey V, Martinsen Amy E, Winsvold Bendik S, Diatchenko Luda
Abstract excerpt
ABSTRACT: Chronic pain is a prevalent disease with increasing clinical challenges. Genome-wide association studies in chronic pain patients have identified hundreds of common pathogenic variants, yet they only explained a portion of individual variance of chronic pain. With the advances in next-generation sequencing technologies, it is now feasible to conduct rarer variants studies in large-scale databases. Here,...
Topics
- Humans
- Chronic Pain
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Neuralgia
- Sulfates
- Symporters