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Article

α‐Ketoglutarate –Dependent KDM6 Histone Demethylases and Interferon‐Stimulated Gene Expression in Lupus

6 Oct 2023

Abstract excerpt

OBJECTIVE: We aimed to investigate the hypothesis that interferon (IFN)-stimulated gene (ISG) expression in systemic lupus erythematosus (SLE) monocytes is linked to changes in metabolic reprogramming and epigenetic regulation of ISG expression. METHODS: Monocytes from healthy volunteers and patients with SLE at baseline or following IFNα treatment were analyzed by extracellular flux analysis, proteomics,...

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PMID: 37800478
DOI: 10.1002/art.42724

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