FBP1 orchestrates keratinocyte proliferation/differentiation and suppresses psoriasis through metabolic control of histone acetylation

Abstract excerpt

<title>Abstract</title> <p>Keratinocyte proliferation and differentiation in epidermis are well controlled and essential for reacting to stimuli such as ultraviolet light. Imbalance between proliferation and differentiation is a characteristic feature of major human skin diseases such as psoriasis and squamous cell carcinoma. However, the effect of keratinocyte metabolism on proliferation and differentiation rema...

Topics

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• Aldehyde Reductase
• Cell Proliferation
• High-Throughput Nucleotide Sequencing
• Histone Deacetylase Inhibitors Research
• Keratinocytes
• Lysosomal Storage Disorders Research
• Psoriasis: Treatment and Pathogenesis
• Vitamin C and Antioxidants Research

Identifiers and source

Literature Corpus work

c5e71358-d56a-582f-a722-d7648abcf2dc

DOI

10.21203/rs.3.rs-3495258/v1