Article

Renal medullary carcinomas depend upon <i>SMARCB1</i> loss and are sensitive to proteasome inhibition

2018-12-05

Abstract excerpt

Renal medullary carcinoma (RMC) is a rare and deadly kidney cancer in patients of African descent with sickle cell trait. Through direct-to-patient outreach, we developed genomically faithful patient-derived models of RMC. Using whole genome sequencing, we identified intronic fusion events in one SMARCB1 allele with concurrent loss of the other allele, confirming that SMARCB1 loss occurs in RMC. Biochemical and f...

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Literature Corpus work: fd85e750-f2ab-59c3-b5a8-3d29a102fe43
DOI: 10.1101/487579

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