Article

Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities

2025-06-20

Abstract excerpt

<h4>SUMMARY</h4> The von Hippel-Lindau tumor suppressor (VHL) is a component of a ubiquitin ligase complex that normally controls cellular responses to hypoxia. Endogenous VHL is also utilized by proteolysis-targeting chimera (PROTAC) protein degraders, a promising class of anti-cancer agents. VHL is broadly essential for cell proliferation, yet it is a key tumor suppressor in renal cell carcinoma. To understand...

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Literature Corpus work: 572634ec-c8ad-5b4d-929b-70cb99b84865
DOI: 10.1101/2025.06.14.659649

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