Article

Restoring p53 Function and Silencing REV3L Suppresses the Cancerous Metabolic Phenotype in Cisplatin Treated Human Non-Small Lung Carcinoma Cells

2017-10-10

Abstract excerpt

Lung cancer is one of the deadliest cancers in the world accounting for over one-quarter of all cancer-related deaths, but in many cases, the cancer can develop a resistance to the cisplatin-based chemotherapies. It is well known that cancer cells exhibit the Warburg effect and some studies have suggested that cancer cell metabolism may be linked to cisplatin resistance. In this study, the effects of tumor suppres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a6d69092-16e3-5a4a-b1f0-d1afd5094ad3
DOI: 10.1101/200816

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Restoring p53 Function and Silencing REV3L Suppresses the Cancerous Metabolic Phenotype in Cisplatin Treated Human Non-Small Lung Carcinoma CellsDOI 10.1101/200816Read

DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.Semantic proximity Read

Cisplatin Resistance and Redox-Metabolic Vulnerability: A Second AlterationSemantic proximity Read

Functional linkage between mitochondrial electron transport, glycolysis, and AMP-activated protein kinase signaling underlying cancer cell survivalSemantic proximity Read

Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death.Semantic proximity Read

Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.Semantic proximity Read

Aldehyde dehydrogenase is used by cancer cells for energy metabolismSemantic proximity Read

Cancer metabolism: fatty acid oxidation in the limelight.Semantic proximity Read

Creatine riboside is a cancer cell–derived metabolite associated with arginine auxotrophySemantic proximity Read

Respiratory complex I‐mediated NAD + regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21 Cip1 expression by SIRT3 and SIRT7Semantic proximity Read

Metabolic vulnerability of cisplatin‐resistant cancersSemantic proximity Read

Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer.Semantic proximity Read

Role of uL3 in Multidrug Resistance in p53-Mutated Lung Cancer Cells.Semantic proximity Read