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Article

DRP1 promotes lactate utilization in KRAS-mutant non-small-cell lung cancer cells.

Cancer science - 1 Oct 2020

Hu Mangze, Zhao Yu, Cao Yuejiao, Tang Qianru, Feng Ziqin, Ni Jun, Zhou Xiaorong

Abstract excerpt

Metabolic alterations are well documented in various cancers. Non-small-cell lung cancers (NSCLCs) preferentially use lactate as the primary carbon source, but the underlying mechanisms are not well understood. We developed a lactate-dependent cell proliferation assay and found that dynamin-related protein (DRP1), which is highly expressed in KRAS-mutant NSCLC, is required for tumor cells to proliferate and uses...

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Identifiers

PMID: 32767829
DOI: 10.1111/cas.14603
PMCID: PMC7540982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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