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Aldehyde dehydrogenase is used by cancer cells for energy metabolism

25 Nov 2016

Abstract excerpt

We found that non-small-cell lung cancer (NSCLC) cells express high levels of multiple aldehyde dehydrogenase (ALDH) isoforms via an informatics analysis of metabolic enzymes in NSCLC and immunohistochemical staining of NSCLC clinical tumor samples. Using a multiple reaction-monitoring mass spectrometry analysis, we found that multiple ALDH isozymes were generally abundant in NSCLC cells compared with their...

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PMID: 27885254
DOI: 10.1038/emm.2016.103

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