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Article

Cancer metabolism: fatty acid oxidation in the limelight.

Nature reviews. Cancer - 1 Apr 2013

Carracedo Arkaitz, Cantley Lewis C, Pandolfi Pier Paolo

Abstract excerpt

Warburg suggested that the alterations in metabolism that he observed in cancer cells were due to the malfunction of mitochondria. In the past decade, we have revisited this idea and reached a better understanding of the 'metabolic switch' in cancer cells, including the intimate and causal relationship between cancer genes and metabolic alterations, and their potential to be targeted for cancer treatment....

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Identifiers

PMID: 23446547
DOI: 10.1038/nrc3483
PMCID: PMC3766957

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