Article
Somatic p53 mutations that are markedly overrepresented in lung cancer confer resistance to reactive oxygen species-induced cell death.
Carcinogenesis - 3 Apr 2025
Tracewell Mason A, Karlin Jonathan E, Barnada Samantha M, McDuffie Elizabeth L, Scott Charles P, Barta Julie A, McMahon Steven B
Abstract excerpt
Lung cancer is among the leading causes of cancer-related death in the US Cigarette smoking remains the leading risk factor for lung cancer and can cause somatic mutations in the critical tumor suppressor gene TP53, among others. Mutations in TP53 not only cause loss of wild-type function but may also introduce oncogenic, gain-of-function (GOF) properties. The frequency of missense mutations at residues p.V157...
Topics
- Humans
- Lung Neoplasms
- Reactive Oxygen Species
- Tumor Suppressor Protein p53
- Oxidative Stress
- Cell Death
- Gain of Function Mutation
- Mutation, Missense
- Cell Line, Tumor
- Mutation