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Article

Loss of the respiratory enzyme citrate synthase directly links the Warburg effect to tumor malignancy.

Scientific reports - 1 Jan 2012

Lin Chin-Chih, Cheng Tsung-Lin, Tsai Wen-Hui, Tsai Hui-Ju, Hu Keng-Hsun, Chang Hao-Chun, Yeh Chin-Wei, Chen Ying-Chou, Liao Ching-Chun, Chang Wen-Tsan

Abstract excerpt

To investigate whether altered energy metabolism induces the Warburg effect and results in tumor malignancy, the respiratory enzyme citrate synthase (CS) was examined, silenced, and the effects analyzed. In human cervical carcinoma cells, RNAi-mediated CS knockdown induced morphological changes characteristic of the epithelial-mesenchymal transition (EMT). This switch accelerated cancer cell metastasis and...

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Identifiers

PMID: 23139858
DOI: 10.1038/srep00785
PMCID: PMC3492867

Genes

SCO2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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