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Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signaling

2026-01-30

Abstract excerpt

<title>Abstract</title> <p>Interleukin-33 (IL-33) is a central regulator of immune responses and inflammation, and genetic variation in IL33 and its receptor IL1RL1 (ST2) is strongly linked to disease susceptibility, notably asthma. Emerging evidence suggests that IL-33 also influences hematopoietic processes and platelet biology, indicating functions beyond canonical immunity. We investigated two missense varian...

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Literature Corpus work
a6d4f269-f2bf-5bd4-abd9-4c6528454750
DOI
10.21203/rs.3.rs-8612877/v1
Open publication

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Structural and functional consequences of IL33 and IL1RL1 coding variants on IL-33/ST2 signalingDOI 10.21203/rs.3.rs-8612877/v1
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