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Article

Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases

1 Jan 2014

Abstract excerpt

Interleukin-33 (IL-33) is a new cytokine of interleukin-1 family, whose specific receptor is ST2. IL-33 exerts its functions via its target cells and plays different roles in diseases. ST2 deletion and exclusion of IL-33/ST2 axis are accompanied by enhanced susceptibility to dominantly T cell-mediated organ-specific autoimmune diseases. It has been reported that IL-33/ST2 pathway plays a key role in host defense...

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PMID: 25032216
DOI: 10.1155/2014/587376

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