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Article

Integrating Structural Information to Study the Dynamics of Protein-Protein Interactions in Cells.

Structure (London, England : 1993) - 2 Oct 2018

Wang Bo, Xie Zhong-Ru, Chen Jiawen, Wu Yinghao

Abstract excerpt

The information of how two proteins interact is embedded in the atomic details of their binding interfaces. These interactions, spatial-temporally coordinating each other as a network in a variable cytoplasmic environment, dominate almost all biological functions. A feasible and reliable computational model is highly demanded to realistically simulate these cellular processes and unravel the complexities beneath...

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PMID: 30174150
DOI: 10.1016/j.str.2018.07.010
PMCID: PMC6582366

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