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Article

Importance of amino acids Leu135 and Tyr236 for the interaction between EhCFIm25 and RNA: a molecular dynamics simulation study.

Journal of molecular modeling - 12 Jul 2018

Ospina-Villa Juan David, García-Contreras Juan, Rosas-Trigueros Jorge Luis, Ramírez-Moreno Esther, López-Camarillo César, Zamora-López Beatriz, Marchat Laurence A, Zamorano-Carrillo Absalom

Abstract excerpt

The CFIm25 subunit of the heterotetrameric cleavage factor Im (CFIm) is a critical factor in the formation of the poly(A) tail at mRNA 3' end, regulating the recruitment of polyadenylation factors, poly(A) site selection, and cleavage/polyadenylation reactions. We previously reported the homologous protein (EhCFIm25) in Entamoeba histolytica, the protozoan causing human amoebiasis, and showed the relevance of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 30003410
DOI: 10.1007/s00894-018-3729-1

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