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Article

The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures.

Proteins - 1 Oct 2013

Seckler James M, Leioatts Nicholas, Miao Hongyu, Grossfield Alan

Abstract excerpt

HIV-1 reverse transcriptase (RT) is a critical drug target for HIV treatment, and understanding the exact mechanisms of its function and inhibition would significantly accelerate the development of new anti-HIV drugs. It is well known that structure plays a critical role in protein function, but for RT, structural information has proven to be insufficient-despite enormous effort-to explain the mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23720322
DOI: 10.1002/prot.24325
PMCID: PMC3773008

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