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Article

Applications of Normal Mode Analysis Methods in Computational Protein Design.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2017

Frappier Vincent, Chartier Matthieu, Najmanovich Rafael

Abstract excerpt

Recent advances in coarse-grained normal mode analysis methods make possible the large-scale prediction of the effect of mutations on protein stability and dynamics as well as the generation of biologically relevant conformational ensembles. Given the interplay between flexibility and enzymatic activity, the combined analysis of stability and dynamics using the Elastic Network Contact Model (ENCoM) method has...

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PMID: 27914052
DOI: 10.1007/978-1-4939-6637-0_9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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