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Article

Early mutation bursts in colorectal tumors.

PloS one - 1 Jan 2017

Zhao Junsong, Salomon Matthew P, Shibata Darryl, Curtis Christina, Siegmund Kimberly, Marjoram Paul

Abstract excerpt

Tumor growth is an evolutionary process involving accumulation of mutations, copy number alterations, and cancer stem cell (CSC) division and differentiation. As direct observation of this process is impossible, inference regarding when mutations occur and how stem cells divide is difficult. However, this ancestral information is encoded within the tumor itself, in the form of intratumoral heterogeneity of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28257429
DOI: 10.1371/journal.pone.0172516
PMCID: PMC5336211

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